26 February 2013 Development of a biodegradable iron oxide nanoparticle gel for tumor bed therapy
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Abstract
Treatments of the post-operative surgical bed have proven appealing as the majority of cancer recurrence following tumor resection occurs at the tumor margin. A novel, biodegradable pullulan-based gel infused with magnetic iron oxide nanoparticles (IONP) is presented here for surgical bed administration followed by hyperthermia therapy via alternating magnetic field (AMF) activation. Pullulan is a water soluble, film-forming starch polymer that degrades at the postoperative wound site to deliver the IONP payload, targeting the remaining cancer cells. Different gel formulations containing various % wt of pullulan were tested for IONP elution. Elution levels and amount of gel degradation were measured by immersing the gel in de-ionized water for one hour then measuring particle concentrations in the supernatant and the mass of the remaining gel formulation. The most promising gel formulations will be tested in a murine model of surgical bed resection to assess in vivo gel dissolution, IONP cell uptake kinetics via histology and TEM analysis, and heating capability of the gel with AMF exposure.
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B. P. Cunkelman, B. P. Cunkelman, E. Y. Chen, E. Y. Chen, A. A. Petryk, A. A. Petryk, J. A. Tate, J. A. Tate, S. G. Thappa, S. G. Thappa, R. J. Collier, R. J. Collier, P. J. Hoopes, P. J. Hoopes, } "Development of a biodegradable iron oxide nanoparticle gel for tumor bed therapy", Proc. SPIE 8584, Energy-based Treatment of Tissue and Assessment VII, 858411 (26 February 2013); doi: 10.1117/12.2007310; https://doi.org/10.1117/12.2007310
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