Intense picosecond THz pulses alter gene expression in human skin tissue in vivo

Lyubov V. Titova; Ayesheshim K. Ayesheshim; Andrey Golubov; Rocio Rodriguez-Juarez; Anna Kovalchuk; Frank A. Hegmann; Olga Kovalchuk

doi:10.1117/12.2004998

23 February 2013 Intense picosecond THz pulses alter gene expression in human skin tissue in vivo

Lyubov V. Titova, Ayesheshim K. Ayesheshim, Andrey Golubov, Rocio Rodriguez-Juarez, Anna Kovalchuk, Frank A. Hegmann, Olga Kovalchuk

Author Affiliations +

Proceedings Volume 8585, Terahertz and Ultrashort Electromagnetic Pulses for Biomedical Applications; 85850Q (2013) https://doi.org/10.1117/12.2004998
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Pulsed terahertz (THz) imaging has been suggested as a novel high resolution, noninvasive medical diagnostic tool. However, little is known about the influence of pulsed THz radiation on human tissue, i.e., its genotoxicity and effects on cell activity and cell integrity. We have carried out a comprehensive investigation of the biological effects of THz radiation on human skin tissue using a high power THz pulse source and an in vivo full-thickness human skin tissue model. We have observed that exposure to intense THz pulses causes DNA damage and changes in the global gene expression profile in the exposed skin tissue. Several of the affected genes are known to play major roles in human cancer. While the changes in the expression levels of some of them suggest possible oncogenic effects of pulsed THz radiation, changes in the expression of the other cancer-related genes might have a protective influence. This study may serve as a roadmap for future investigations aimed at elucidating the exact roles that all the affected genes play in skin carcinogenesis and in response to pulsed THz radiation.

Citation Download Citation

Lyubov V. Titova, Ayesheshim K. Ayesheshim, Andrey Golubov, Rocio Rodriguez-Juarez, Anna Kovalchuk, Frank A. Hegmann, and Olga Kovalchuk "Intense picosecond THz pulses alter gene expression in human skin tissue in vivo", Proc. SPIE 8585, Terahertz and Ultrashort Electromagnetic Pulses for Biomedical Applications, 85850Q (23 February 2013); https://doi.org/10.1117/12.2004998

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available