23 February 2013 Identification of tissue interaction of terahertz radiation toward functional tissue imaging
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Abstract
In recent years, many applications have been recognized for biomedical imaging techniques utilizing terahertz frequency radiation. This is largely due to the capability of unique tissue identification resulting from the nature of the interaction between THz radiation and the molecular structure of the cells. By THz identification methods, tissue changes in tooth enamel, cartilage, and malignant cancer cells have already been demonstrated. Terahertz Time-Domain Spectroscopy (THz-TDS) remains one of the most versatile methods for spectroscopic image acquisition for its ability to simultaneously determine amplitude and phase over a broad spectral range. In this study we investigate the use of THz imaging techniques to uniquely identify damage types in tissue samples for both forensic and treatment applications. Using THz-TDS imaging in both transmission and reflection schemes, we examine tissue samples which have been damaged using a variety of acids. Each method of damage causes structural deterioration to the tissue by a different mechanism, thus leaving the remaining tissue uniquely changed based on the damage type. We correlate the change in frequency spectra, phase shift for each damage type to the mechanisms and severity of injury.
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Hamdullah Yokus, William Baughman, Soner Balci, Michael Bolus, David Wilbert, Patrick Kung, Seongsin M. Kim, "Identification of tissue interaction of terahertz radiation toward functional tissue imaging", Proc. SPIE 8585, Terahertz and Ultrashort Electromagnetic Pulses for Biomedical Applications, 85850K (23 February 2013); doi: 10.1117/12.2005586; https://doi.org/10.1117/12.2005586
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