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23 February 2013Neurostimulation using subnanosecond electric pulses
We have for the first time recorded action potentials in rat hippocampus neurons when they were stimulated by
subnanosecond electric pulses. The preliminary results show that applying a series of pulses allowed the accumulation of
depolarization before activating the voltage gated channels. The depolarization only occurred when the electric pulses
were applied. It is unclear whether the depolarization is caused by the charge accumulation across the membrane or the
cation influx due to the membrane permeabilization. We have also conducted an electromagnetic simulation of
delivering subnanosecond pulses to tissues using an impulse radiating antenna. The results show that the pulses can be
confined in the deep region in the brain but the amplitude is reduced significantly due to the attenuation of the tissues. A
partially lossy dielectric lens may be used to reverse the decreasing trend of the electric field.
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Shu Xiao, Andrei Pakhomov, Fei Guo, Swetha Polisetty, Karl H. Schoenbach, "Neurostimulation using subnanosecond electric pulses," Proc. SPIE 8585, Terahertz and Ultrashort Electromagnetic Pulses for Biomedical Applications, 85850M (23 February 2013);