24 April 2013 Reflective terahertz (THz) imaging: system calibration using hydration phantoms
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Abstract
Terahertz (THz) hydration sensing continues to gain traction in the medical imaging community due to its unparalleled sensitivity to tissue water content. Rapid and accurate detection of fluid shifts following induction of thermal skin burns as well as remote corneal hydration sensing have been previously demonstrated in vivo using reflective, pulsed THz imaging. The hydration contrast sensing capabilities of this technology were recently confirmed in a parallel 7 Tesla Magnetic Resonance (MR) imaging study, in which burn areas are associated with increases in local mobile water content. Successful clinical translation of THz sensing, however, still requires quantitative assessments of system performance measurements, specifically hydration concentration sensitivity, with tissue substitutes. This research aims to calibrate the sensitivity of a novel, reflective THz system to tissue water content through the use of hydration phantoms for quantitative comparisons of THz hydration imagery.Gelatin phantoms were identified as an appropriate tissue-mimicking model for reflective THz applications, and gel composition, comprising mixtures of water and protein, was varied between 83% to 95% hydration, a physiologically relevant range. A comparison of four series of gelatin phantom studies demonstrated a positive linear relationship between THz reflectivity and water concentration, with statistically significant hydration sensitivities (p < .01) ranging between 0.0209 - 0.038% (reflectivity: %hydration). The THz-phantom interaction is simulated with a three-layer model using the Transfer Matrix Method with agreement in hydration trends. Having demonstrated the ability to accurately and noninvasively measure water content in tissue equivalent targets with high sensitivity, reflective THz imaging is explored as a potential tool for early detection and intervention of corneal pathologies.
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Neha Bajwa, Neha Bajwa, James Garritano, James Garritano, Yoon Kyung Lee, Yoon Kyung Lee, Priyamvada Tewari, Priyamvada Tewari, Shijun Sung, Shijun Sung, Ashkan Maccabi, Ashkan Maccabi, Bryan Nowroozi, Bryan Nowroozi, Meghedi Babakhanian, Meghedi Babakhanian, Sajan Sanghvi, Sajan Sanghvi, Rahul Singh, Rahul Singh, Warren Grundfest, Warren Grundfest, Zachary Taylor, Zachary Taylor, } "Reflective terahertz (THz) imaging: system calibration using hydration phantoms", Proc. SPIE 8585, Terahertz and Ultrashort Electromagnetic Pulses for Biomedical Applications, 85850W (24 April 2013); doi: 10.1117/12.2001913; https://doi.org/10.1117/12.2001913
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