Multifractal detrended fluctuation analysis of optogenetic modulation of neural activity

S. Kumar; L. Gu; N. Ghosh; S. K. Mohanty

doi:10.1117/12.2007689

22 February 2013 Multifractal detrended fluctuation analysis of optogenetic modulation of neural activity

S. Kumar, L. Gu, N. Ghosh, S. K. Mohanty

Proceedings Volume 8586, Optogenetics: Optical Methods for Cellular Control; 858608 (2013) https://doi.org/10.1117/12.2007689
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Here, we introduce a computational procedure to examine whether optogenetically activated neuronal firing recordings could be characterized as multifractal series. Optogenetics is emerging as a valuable experimental tool and a promising approach for studying a variety of neurological disorders in animal models. The spiking patterns from cortical region of the brain of optogenetically-stimulated transgenic mice were analyzed using a sophisticated fluctuation analysis method known as multifractal detrended fluctuation analysis (MFDFA). We observed that the optogenetically-stimulated neural firings are consistent with a multifractal process. Further, we used MFDFA to monitor the effect of chemically induced pain (formalin injection) and optogenetic treatment used to relieve the pain. In this case, dramatic changes in parameters characterizing a multifractal series were observed. Both the generalized Hurst exponent and width of singularity spectrum effectively differentiates the neural activities during control and pain induction phases. The quantitative nature of the analysis equips us with better measures to quantify pain. Further, it provided a measure for effectiveness of the optogenetic stimulation in inhibiting pain. MFDFA-analysis of spiking data from other deep regions of the brain also turned out to be multifractal in nature, with subtle differences in the parameters during pain-induction by formalin injection and inhibition by optogenetic stimulation. Characterization of neuronal firing patterns using MFDFA will lead to better understanding of neuronal response to optogenetic activation and overall circuitry involved in the process.

Citation Download Citation

S. Kumar, L. Gu, N. Ghosh, and S. K. Mohanty "Multifractal detrended fluctuation analysis of optogenetic modulation of neural activity ", Proc. SPIE 8586, Optogenetics: Optical Methods for Cellular Control, 858608 (22 February 2013); https://doi.org/10.1117/12.2007689

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