Hyperspectral angular domain imaging for ex-vivo breast tumor detection

Fartash Vasefi; Bozena Kaminska; Muriel Brackstone; Jeffrey J. L. Carson

doi:10.1117/12.2004663

20 June 2013 Hyperspectral angular domain imaging for ex-vivo breast tumor detection

Fartash Vasefi, Bozena Kaminska, Muriel Brackstone, Jeffrey J. L. Carson

Proceedings Volume 8587, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XI; 85870S (2013) https://doi.org/10.1117/12.2004663
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

An angular domain spectroscopic imaging system was built and validated using fresh ex vivo breast tissue samples (~ 2 mm thick). The hyperspectral system consisted of a halogen lamp, collimation optics, scanning stage with controller, a silicon micro-machined micro-channel array, and a pushbroom spectral imager. As a proof of concept, spectral data cubes acquired from tissue samples were input into principal component analysis and Mahalanobis discriminant analysis to differentiate between spectral signatures of breast tumor and normal tissue. It is proposed that the results from training sets can be used to construct a set of classifiers to enable tumor detection in samples representative of the surgical margins.

Citation Download Citation

Fartash Vasefi, Bozena Kaminska, Muriel Brackstone, and Jeffrey J. L. Carson "Hyperspectral angular domain imaging for ex-vivo breast tumor detection", Proc. SPIE 8587, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XI, 85870S (20 June 2013); https://doi.org/10.1117/12.2004663

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