22 February 2013 New developments in clinical CARS
Author Affiliations +
Proceedings Volume 8588, Multiphoton Microscopy in the Biomedical Sciences XIII; 85881E (2013); doi: 10.1117/12.2001855
Event: SPIE BiOS, 2013, San Francisco, California, United States
We combined two-photon fluorescence and coherent anti-Stokes Raman scattering (CARS) imaging in a clinical hybrid multiphoton tomograph for in vivo imaging of human skin. The clinically approved TPEF/CARS system provides simultaneous imaging of endogenous fluorophores and non-fluorescent lipids. The Stokes laser for the two-beam configuration of CARS is based on spectral broadening of femtosecond laser pulses in a photonic crystal fiber (PCF). We report on the highly flexible medical TPEF/CARS tomograph MPTflex®-CARS with an articulated arm and first in vivo measurements on human skin.
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Martin Weinigel, Hans Georg Breunig, Marcel Kellner-Höfer, Rainer Bückle, Maxim Darvin, Juergen Lademann, Karsten König, "New developments in clinical CARS", Proc. SPIE 8588, Multiphoton Microscopy in the Biomedical Sciences XIII, 85881E (22 February 2013); doi: 10.1117/12.2001855; https://doi.org/10.1117/12.2001855


CARS tomography

In vivo imaging

Tissue optics

Femtosecond phenomena

Signal detection

Biomedical optics


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