25 February 2013 The study of esophageal cancer in an early stage by using Raman spectroscopy
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The esophageal cancer is a disease with a high mortality. In order to lead a higher survival rate five years after the cancer’s treatment, we inevitably need a method to diagnose the cancer in an early stage and support the therapy. Raman spectroscopy is one of the most powerful techniques for the purpose. In the present study, we apply Raman spectroscopy to obtain ex vivo spectra of normal and early tumor human esophageal sample. The result of principal component analysis indicates that the tumor tissue is associated with a decrease in tryptophan concentration. Furthermore, we can predict the tissue type with 80% accuracy by linear discriminant analysis which model is made by tryptophan bands.
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Mika Ishigaki, Mika Ishigaki, Akinori Taketani, Akinori Taketani, Yasuhiro Maeda, Yasuhiro Maeda, Bibin B. Andriana, Bibin B. Andriana, Ryu Ishihara, Ryu Ishihara, Hidetoshi Sato, Hidetoshi Sato, "The study of esophageal cancer in an early stage by using Raman spectroscopy", Proc. SPIE 8591, Optical Diagnostics and Sensing XIII: Toward Point-of-Care Diagnostics, 859109 (25 February 2013); doi: 10.1117/12.2005662; https://doi.org/10.1117/12.2005662

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