Tunable mid-infrared laser spectroscopy based on fiber-optic sensor for glucose measurement

Songlin Yu; Dachao Li; Hao Chong; Changyue Sun; Kexin Xu

doi:10.1117/12.2002781

25 February 2013 Tunable mid-infrared laser spectroscopy based on fiber-optic sensor for glucose measurement

Songlin Yu, Dachao Li, Hao Chong, Changyue Sun, Kexin Xu

Proceedings Volume 8591, Optical Diagnostics and Sensing XIII: Toward Point-of-Care Diagnostics; 85910K (2013) https://doi.org/10.1117/12.2002781
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

The application of tunable Mid-infrared laser system based on fiber-optic ATR sensor to regent-free quantification of glucose concentration was presented. The five laser emission wavelengths, including 1081, 1076, 1051, 1041 and 1037 cm^-1, were employed for glucose determination. In our experiments, absorbance at the five wavelengths correlates strongly well with glucose concentration (R²>0.99, SD<0.0004, P<0.0001), and the noise-equivalent concentration is as low as 3.8 mg/dL. Compared with the conventional FT-IR spectrometer, higher sensitivity was aquired because of the laser higher power and spectral resolution, and it is about 4 times as high as that of FT-IR spectrometer. All the results of this investigation suggested that the tunable CO₂ laser spectroscopy is a powerful method for glucose measurement. Especially, the multiple tunable wavelengths, which makes it possible for glucose determination in blood or interstitial fluide with complicated components.

Citation Download Citation

Songlin Yu, Dachao Li, Hao Chong, Changyue Sun, and Kexin Xu "Tunable mid-infrared laser spectroscopy based on fiber-optic sensor for glucose measurement", Proc. SPIE 8591, Optical Diagnostics and Sensing XIII: Toward Point-of-Care Diagnostics, 85910K (25 February 2013); https://doi.org/10.1117/12.2002781

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