21 February 2013 On alterations in the refractive index and scattering properties of biological tissue caused by histological processing
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Abstract
Clinical tissue processing such as formalin fixing, paraffin-embedding and histological staining alters significantly the optical properties of the tissue. We document the alterations in the optical properties of prostate cancer tissue specimens in the 500nm to 700nm spectral range caused by histological processing with quantitative differential interference contrast (qDIC) microscopy. A simple model to explain these alterations is presented at the end.
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Htet Aung, Htet Aung, Bianca DeAngelo, Bianca DeAngelo, John Soldano, John Soldano, Piotr Kostyk, Piotr Kostyk, Braulio Rodriguez, Braulio Rodriguez, M. Xu, M. Xu, } "On alterations in the refractive index and scattering properties of biological tissue caused by histological processing", Proc. SPIE 8592, Biomedical Applications of Light Scattering VII, 85920X (21 February 2013); doi: 10.1117/12.2005927; https://doi.org/10.1117/12.2005927
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