26 March 2013 Effect of alcohol exposure on fetal brain development
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Abstract
Alcohol consumption during pregnancy can be severely damage to the brain development in fetuses. This study investigates the effects of maternal ethanol consumption on brain development in mice embryos. Pregnant mice at gestational day 12.5 were intragastrically gavaged with ethanol (3g/Kg bwt) twice daily for three consecutive days. On gestational day 14.5, fetuses were collected and fixed in 4% paraformaldehyde and imaged using a swept-source optical coherence tomography (SSOCT) system. 3D images of the mice embryo brain were obtained and the volumes of the left and right ventricles of the brain were measured. The average volumes of the left and the right volumes of 5 embryos each alcohol-exposed and control embryos were measured to be 0.35 and 0.15 mm3, respectively. The results suggest that the left and right ventricle volumes of brain are much larger in the alcohol-exposed embryos as compared to control embryos indicating alcohol-induced developmental delay.
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Narendran Sudheendran, Narendran Sudheendran, Shameena Bake, Shameena Bake, Rajesh C. Miranda, Rajesh C. Miranda, Kirill V. Larin, Kirill V. Larin, } "Effect of alcohol exposure on fetal brain development ", Proc. SPIE 8593, Optical Methods in Developmental Biology, 85930I (26 March 2013); doi: 10.1117/12.2006226; https://doi.org/10.1117/12.2006226
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