19 February 2013 Application of phase shift ring down spectroscopy to microcavities for biosensing
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Abstract
Phase shift ring down measurement approach (PS-CRDS) is used to develop a real time biosensor which can simultaneously track the quality factor Q and the resonant wavelength λr of microcavities as a function of the biodetection event. We have developed a mathematical model to predict the binding event with high accuracy by utilizing the information from these two physical parameters (Q and λr). Experiments are also conducted to validate the model. Hence, PS-CRDS biosensor in conjunction with the estimation model, will pave the way for highly sensitive measurements of biological entities/processes ranging from micron to nano scale.
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M. Imran Cheema, Usman A. Khan, Andrea M. Armani, Andrew G. Kirk, "Application of phase shift ring down spectroscopy to microcavities for biosensing", Proc. SPIE 8594, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications X, 859401 (19 February 2013); doi: 10.1117/12.2011779; https://doi.org/10.1117/12.2011779
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