19 February 2013 Label-free imaging of live cell using large-scale photonic crystal nanolaser array
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Abstract
We integrated 441 photonic crystal nanolasers and applied it to label-free live cell imaging. Since the mechanical strength of the nanolaser array was improved by bonding on a glass substrate, the imaging area was expanded from previous 25 × 25 μm2 to 100 × 100 μm2. We successfully acquired cell images, which should reflect the intracellular and/or the attachment conditions. By continuously mapping the wavelengths of all nanolasers, we successfully observed the time-dependent images displaying the cell behaviors. Reagents were injected to stimulate the cells, and the observation was continued until the cell reaction was saturated. The results show the reasonable behaviors against the reagents.
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Hiroshi Abe, Michimasa Narimatsu, Shota Kita, Kosuke Nakamura, Satoshi Ota, Yasushi Takemura, Toshihiko Baba, "Label-free imaging of live cell using large-scale photonic crystal nanolaser array", Proc. SPIE 8594, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications X, 859404 (19 February 2013); doi: 10.1117/12.2003806; https://doi.org/10.1117/12.2003806
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