19 February 2013 Self-referenced silicon nitride array microring biosensor for toxin detection using glycans at visible wavelength
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Abstract
We report on application of on-chip referencing to improve the limit-of-detection (LOD) in compact silicon nitride (SiN) microring arrays. Microring resonators, fabricated by e-beam lithography and fluorine-based etching, are designed for visible wavelengths (656nm) and have a footprint of 20 x 20 μm. GM1 ganglioside is used as the specific ligand for recognition of Cholera Toxin Subunit B (CTB), with Ricinus Communis Agglutinin I (RCA I) as a negative control. Using micro-cantilever based printing less than 10 pL of glycan solution is consumed per microring. Real-time data on analyte binding is extracted from the shifts in resonance wavelengths of the microrings.
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Farshid Ghasemi, Ali A. Eftekhar, David S. Gottfried, Xuezheng Song, Richard D. Cummings, Ali Adibi, "Self-referenced silicon nitride array microring biosensor for toxin detection using glycans at visible wavelength", Proc. SPIE 8594, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications X, 85940A (19 February 2013); doi: 10.1117/12.2005653; https://doi.org/10.1117/12.2005653
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