22 February 2013 Single-nanoparticle detection and spectroscopy in cells using a hyperspectral darkfield imaging technique
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Abstract
We discuss a hyperspectral darkfield microscopy technique capable of imaging single nanoparticles at biologically compatible (<0.5 W/cm2) illumination conditions. The microscope was tested on an array of lithographically produced gold nanorod antennas and on colloidal gold nanorods deposited on a glass substrate. As a test for in-vitro imaging capabilities, we studied the uptake of gold nanorods by DC2.4 dendritic cells.
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Natasha Fairbairn, Natasha Fairbairn, Rute Fernandes, Rute Fernandes, Rachel Carter, Rachel Carter, Timothy J. Elliot, Timothy J. Elliot, Antonios G. Kanaras, Antonios G. Kanaras, Otto L. Muskens, Otto L. Muskens, } "Single-nanoparticle detection and spectroscopy in cells using a hyperspectral darkfield imaging technique", Proc. SPIE 8595, Colloidal Nanocrystals for Biomedical Applications VIII, 859501 (22 February 2013); doi: 10.1117/12.981941; https://doi.org/10.1117/12.981941
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