22 February 2013 Colloidal gold nanorings for improved photodynamic therapy through field-enhanced generation of reactive oxygen species
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Abstract
Au nanostructures that exhibit strong localized surface plasmon resonance (SPR) have excellent potential for photo-medicine, among a host of other applications. Here, we report the synthesis and use of colloidal gold nanorings (GNRs) with potential for enhanced photodynamic therapy of cancer. The GNRs were fabricated via galvanic replacement reaction of sacrificial Co nanoparticles in gold salt solution with low molecular weight (Mw = 2,500) poly(vinylpyrrolidone) (PVP) as a stabilizing agent. The size and the opening of the GNRs were controlled by the size of the starting Co particles and the concentration of the gold salt. UV-Vis absorption measurements indicated the tunability of the SPR of the GNRs from 560 nm to 780 nm. MTT assay showed that GNRs were non-toxic and biocompatible when incubated with breast cancer cells as well as the healthy counterpart cells. GNRs conjugated with 5-aminolevulinic acid (5-ALA) photosensitizer precursor led to elevated formation of reactive oxygen species and improved efficacy of photodynamic therapy of breast cancer cells under light irradiation compared to 5-ALA alone. These results can be attributed to significantly enhance localized electromagnetic field of the GNRs.
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Yue Hu, Yue Hu, Yamin Yang, Yamin Yang, Hongjun Wang, Hongjun Wang, Henry Du, Henry Du, } "Colloidal gold nanorings for improved photodynamic therapy through field-enhanced generation of reactive oxygen species", Proc. SPIE 8595, Colloidal Nanocrystals for Biomedical Applications VIII, 85950B (22 February 2013); doi: 10.1117/12.2001155; https://doi.org/10.1117/12.2001155
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