22 February 2013 Nanoprecipitation versus two step desolvation technique for the preparation of gelatin nanoparticles
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Various techniques have been used for preparation of gelatin nanoparticles, such as coacervation, emulsion/solvent evaporation, reverse phase preparation, inverse miniemulsion and two step desolvation. Both methods are based on different mechanisms of nanoparticle formation. The main goal of this study was to systematically compare the performance of nanoprecipitation and the most widely utilized two step desolvation methods with respect to effect of gelatin concentration on nanoparticle size and polydispersity index. Particles size was determined by dynamic light scattering, and the morphology by atomic force microscopy. It was observed that gelatin concentration 20 mg/ml yielded nanoparticles of around 60 nm size by two step desolvation, on the other hand nanoprecipitation produced 210 nm particles with the same gelatin concentration.
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Saeed Ahmad Khan, Saeed Ahmad Khan, Marc Schneider, Marc Schneider, } "Nanoprecipitation versus two step desolvation technique for the preparation of gelatin nanoparticles", Proc. SPIE 8595, Colloidal Nanocrystals for Biomedical Applications VIII, 85950H (22 February 2013); doi: 10.1117/12.2002419; https://doi.org/10.1117/12.2002419

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