You have requested a machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Neither SPIE nor the owners and publishers of the content make, and they explicitly disclaim, any express or implied representations or warranties of any kind, including, without limitation, representations and warranties as to the functionality of the translation feature or the accuracy or completeness of the translations.
Translations are not retained in our system. Your use of this feature and the translations is subject to all use restrictions contained in the Terms and Conditions of Use of the SPIE website.
22 February 2013Examination of pterins using surface-enhanced Raman spectroscopy using low-volume samples
Raman spectroscopy is a very useful tool for analysing compounds, however its ability to detect low concentrations of a substance are very limited. Surface Enhanced Raman Spectroscopy (SERS) overcomes that issue and is reported to have achieved single molecule detection. Its main shortcoming is the reproducibility of SERS spectra. The variation in signal strength prevents SERS from being usable as a quantitative analytical technique. This variability have been investigated in this work and key factors in improving reproducibility have been considered.
Pterins, such as xanthopterin are studied in this paper. Pterins are a group of biological compounds that are found in
nature in colour pigmentation and in mammal’s metabolic pathways. Moreover, they have been identified in abnormal
concentrations in the urine of people suffering from certain kinds of cancer. The potential for pterin’s use as a cancer
diagnostic points to the importance of SERS detection for pterins.
The alert did not successfully save. Please try again later.
Sam Mehigan, Ciarán Smyth, Eithne M. McCabe, "Examination of pterins using surface-enhanced Raman spectroscopy using low-volume samples ," Proc. SPIE 8595, Colloidal Nanocrystals for Biomedical Applications VIII, 85950Y (22 February 2013); https://doi.org/10.1117/12.2003696