13 March 2013 Highly efficient multifunctional MnSe/ZnSeS quantum dots for biomedical applications
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Abstract
Colloidal quantum dots (QDs) are of interest for a variety of biomedical applications, including bioimaging, drug targeting, and photodynamic therapy. However, a significant limitation is that highly efficient photoluminescent QDs available commercially contain cadmium. Recent research has focused on cadmium-free QDs, which are anticipated to exhibit significantly lower cytotoxicity. Previous work has focused on InP and ZnO as alternative semiconductor materials for QDs. However, these nanoparticles have been shown to be cytotoxic. Recently, we have synthesized high quantum efficiency (exceeding 90%), color tunable MnSe/ZnSeS nanoparticles, as potentially attractive QDs for biomedical applications. Additionally, the manganese imparts magnetic properties on the QDs, which are important for magnetic field-guided transport, hyperthermia, and potentially magnetic resonance imaging (MRI). The QDs can be further biofunctionalized via conjugation to a ligand or a biomarker of disease, allowing combination of drug delivery with visual verification and colocalization due to the color tunability of the QDs.
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Leisha M. Armijo, Leisha M. Armijo, Brian A. Akins, Brian A. Akins, John B. Plumley, John B. Plumley, Antonio C. Rivera, Antonio C. Rivera, Nathan J. Withers, Nathan J. Withers, Nathaniel C. Cook, Nathaniel C. Cook, Gennady A. Smolyakov, Gennady A. Smolyakov, Dale L. Huber, Dale L. Huber, Hugh D. C. Smyth, Hugh D. C. Smyth, Marek Osiński, Marek Osiński, } "Highly efficient multifunctional MnSe/ZnSeS quantum dots for biomedical applications", Proc. SPIE 8595, Colloidal Nanocrystals for Biomedical Applications VIII, 859517 (13 March 2013); doi: 10.1117/12.2009563; https://doi.org/10.1117/12.2009563
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