21 February 2013 Near-infrared light-triggered dissociation of block copolymer micelles for controlled drug release
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Abstract
In this manuscript, a new near-infrared (NIR) light-breakable amphiphilic block copolymer containing light-sensitive triggering group on the hydrophobic block was developed. By encapsulating NIR dye cypate inside micelles of poly (N-succinyl-N'-4- (2-nitrobenzyloxy)-succinyl chitosan) and exposing the micellar solution to 765.9 nm light, the photo-cleavage reaction was activated and leading to the dissociation of micelles and release of co-loaded hydrophobic species. The UV-vis absorption spectra, fourier transform infrared (FTIR) spectra and 1H nuclear magnetic resonance (1H NMR) spectra of micelles were characterized. Triggered burst release of the payload upon NIR irradiation and subsequent degradation of the micelles were observed by transmission electron microscopy (TEM). This system represents a general and efficient method to circumvent the need for UV or visible light excitation that is a common drawback for light-responsive polymeric systems developed for potential biomedical applications.
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Jie Cao, Shanshan Huang, Yuqi Chen, Siwen Li, Samuel Achilefu, Zhiyu Qian, Yueqing Gu, "Near-infrared light-triggered dissociation of block copolymer micelles for controlled drug release", Proc. SPIE 8596, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V, 859606 (21 February 2013); doi: 10.1117/12.2003247; https://doi.org/10.1117/12.2003247
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