Lanthanide-doped nanoparticles for hybrid x-ray/optical imaging

L. Sudheendra; Gautom K. Das; C. Li; Simon R. Cherry; Ian M. Kennedy

doi:10.1117/12.2005250

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21 February 2013 Lanthanide-doped nanoparticles for hybrid x-ray/optical imaging

L. Sudheendra, Gautom K. Das, C. Li, Simon R. Cherry, Ian M. Kennedy

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Proceedings Volume 8596, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V; 85960D (2013) https://doi.org/10.1117/12.2005250
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Some lanthanide-doped nanoparticles can absorb X-ray radiation and emit in the visible to near infrared spectrum via a down-conversion mechanism, making them a potentially valuable agent for in vivo imaging studies. We have studied a series of Gd³⁺ and Eu³⁺compositions in lanthanide fluorides to optimize the emission from Eu³⁺ upon X-ray excitation. The optimum concentration of Eu³⁺ that produced the most intense emission in NaGdF₄ was found to be 15% molar concentration. The impact of the crystallographic phases (i.e. cubic or hexagonal) on the optical emission was investigated. Furthermore, an attempt to include a sensitizer (i.e Ce³⁺) in NaGdF₄:Eu resulted in a reduction in the emission following X-ray excitation. A surface coating of NaGdF₄:Eu nanoparticles with a gold shell showed a similar decrease in luminescence intensity by a factor of two although the gold shell offers other advantages in biomedical applications.

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L. Sudheendra, Gautom K. Das, C. Li, Simon R. Cherry, and Ian M. Kennedy "Lanthanide-doped nanoparticles for hybrid x-ray/optical imaging", Proc. SPIE 8596, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V, 85960D (21 February 2013); https://doi.org/10.1117/12.2005250

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