One of the In-vivo system's challenge is real time display the sensing information. Usually Ultrasound, CT, MRI, PET
are used to get the internal information, this thesis proposed another approach to address the display challenge. Special
nano-particles are in-taken or injected to living subject (usually into blood circulation) to sense and collect psychological
information when the active particles pass through the tissues of interest. Using the wound healing mechanism, these
activated particles (Information collected) can be drifted out to the wound area and adhibited close to the skin, then skin
can show different color if the activated particles are concentrated enough in the specific area to create a skin screen. The
skin screen can display the blood status, internal organ's temperature, pressure depending the nano-particles' function and
their pathway. This approach can also be used to display in-body video if the particles are sensitive and selective enough.
In the future, the skin screen can be bio-computer's monitor.
The wound healing in an animal model normally divides in four phase: Hemostasis, Inflammation, Proliferation and
Maturation. Hemostasis phase is to form a stable clot sealing the damaged vessel. Inflammation phase causes the blood
vessels to become leaky releasing plasma and PMN’s (polymorphonucleocytes) into the surrounding tissue and provide
the first line of defense against infection. Proliferation phase involves replacement of dermal tissues and sometimes
subdermal tissues in deeper wounds as well as contraction of the wound. Maturation phase remodels the dermal tissues
mainly by fibroblast to produce greater tensile strength. The skin screen wound will be carefully controlled to be
triggered at dermis layer.