12 April 2013 Biomimetic polydopamine coating on gold nanorods for biofunctionalization, imaging, and photothermal therapy
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Abstract
A biomimetic polydopamine (PD)-based strategy was employed for presenting antibodies on gold nanorods (NRs) to target cancer cells for photothermal therapy. PD was polymerized onto NRs, and epidermal growth factor receptor antibodies (anti-EGFR) were immobilized onto the layer. Anti-EGFR-PD-NRs specifically bound to EGFRoverexpressing cells as quantified by optical coherence tomography, and illumination enhanced cell death compared to non-irradiated or antibody-free controls.
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Kvar C. L. Black, Kvar C. L. Black, Ji Yi, Ji Yi, José G. Rivera, José G. Rivera, Daria C. Zelasko-Leon, Daria C. Zelasko-Leon, Phillip B. Messersmith, Phillip B. Messersmith, } "Biomimetic polydopamine coating on gold nanorods for biofunctionalization, imaging, and photothermal therapy", Proc. SPIE 8598, Bioinspired, Biointegrated, Bioengineered Photonic Devices, 85980D (12 April 2013); doi: 10.1117/12.2005041; https://doi.org/10.1117/12.2005041
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