12 April 2013 Transient Fourier holography with bacteriorhodopsin films for breast cancer diagnostics
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Abstract
X-ray mammography is the current gold standard for breast cancer screening. Microcalcifications and other features which are helpful to the radiologist for early diagnostics are often buried in the noise generated by the surrounding dense tissue. So image processing techniques are required to enhance these important features to improve the sensitivity of detection. An innovative technique is demonstrated for recording a hologram of the mammogram. It is recorded on a thin polymer film of Bacteriorhodopsin (bR) as photo induced isomerization grating containing the interference pattern between the object beam containing the Fourier spatial frequency components of the mammogram and a reference beam. The hologram contains all the enhanced features of the mammogram. A significant innovation of the technique is that the enhanced components in the processed image can be viewed by the radiologist in time scale. A technician can record the movie and when the radiologist looks at the movie at his convenience, freezing the frame as and when desired, he would see the microcalcifications as the brightest and last long in time. He would also observe lesions with intensity decreasing as their size increases. The same bR film can be used repeatedly for recording holograms with different mammograms. The technique is versatile and a different frequency band can be chosen to be optimized by changing the reference beam intensity. The experimental arrangement can be used for mammograms in screen film or digital format.
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Devulapalli Rao, Sri-Rajasekar Kothapalli, Pengfei Wu, Chandra Yelleswarapu, "Transient Fourier holography with bacteriorhodopsin films for breast cancer diagnostics", Proc. SPIE 8598, Bioinspired, Biointegrated, Bioengineered Photonic Devices, 85980K (12 April 2013); doi: 10.1117/12.2020227; https://doi.org/10.1117/12.2020227
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