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15 March 2013 Label free optimal dynamic discrimination of biological macromolecules
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The fast development of laser techniques, in particular, the generation of ultrashort femtosecond and even attosecond pulses opens new frontiers and various experimental tools for biomedical applications. The combination of pulse shaping and optimal control is a very promising tool based on coherent manipulation of wavepackets on an ultrafast time scale. It already has successfully been applied for optimal dynamic discrimination (ODD) experiments of biomolecules like free amino acids and flavins which are indistinguishable by spectroscopic means. This approach can be extended toward to label free cellular imaging and detection of chemical or biological substances.
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S. Afonina, A. Rondi, D. Kiselev, L. Bonacina, and J. P. Wolf "Label free optimal dynamic discrimination of biological macromolecules", Proc. SPIE 8611, Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XIII, 86110F (15 March 2013);

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