13 March 2013 Stationary microfluidics: molecular diagnostic assays by moving magnetic beads through non-moving liquids
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Abstract
Commonly, microfluidic devices are based on the movement of fluids. For molecular diagnostics assays which often include steps like PCR, this practically always involves a more or less complicated set of external pumps, valves and liquid controls. In the presented paper, we follow a different approach in which the fluid after sample introduction remains stationary and the main bioactive sample molecules are moved through a chain of reaction compartments which contain the different reagents necessary for the assay. The big advantage of this concept is the lack of any external fluid actuation/control. Results on sample carry-over experiments and complete assays will be given.
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Holger Becker, Cornelia Carstens, Dirk Kuhlmeier, Natalia Sandetskaya, Nicole Schröter, Christian Zilch, Claudia Gärtner, "Stationary microfluidics: molecular diagnostic assays by moving magnetic beads through non-moving liquids ", Proc. SPIE 8615, Microfluidics, BioMEMS, and Medical Microsystems XI, 86150B (13 March 2013); doi: 10.1117/12.2004041; https://doi.org/10.1117/12.2004041
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