9 March 2013 Programming paper networks for point of care diagnostics
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Abstract
Lateral flow tests (LFTs) are well-suited for rapid point-of-care testing in low resource settings. The wicking action of the paper strip moves the sample and reagents through the device without a need for pumps, but LFTs are typically limited to tests that can be carried out in a single fluidic step. The materials from LFTs can be reconfigured to create paper networks that automatically carry out multi-step fluidic operations, while retaining the same easy-to-use format as a conventional LFT. Here, we describe basic principles of wicking and system-level behavior of paper networks by analogy to electrical circuits. We describe key design principles for a previously-developed 2D paper network (2DPN) and introduce an alternative linear paper network (Pseudo-1DPN) that takes advantage of system-level behavior to perform clean sequential fluid delivery while reducing device running time.
© (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Shivani Dharmaraja, Shivani Dharmaraja, Lisa Lafleur, Lisa Lafleur, Samantha Byrnes, Samantha Byrnes, Peter Kauffman, Peter Kauffman, Josh Buser, Josh Buser, Bhushan Toley, Bhushan Toley, Elain Fu, Elain Fu, Paul Yager, Paul Yager, Barry Lutz, Barry Lutz, } "Programming paper networks for point of care diagnostics", Proc. SPIE 8615, Microfluidics, BioMEMS, and Medical Microsystems XI, 86150X (9 March 2013); doi: 10.1117/12.2006138; https://doi.org/10.1117/12.2006138
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