5 March 2013 Liquid crystal based biosensors for bile acid detection
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Abstract
The concentration level of bile acids is a useful indicator for early diagnosis of liver diseases. The prevalent measurement method in detecting bile acids is the chromatography coupled with mass spectrometry, which is precise yet expensive. Here we present a biosensor platform based on liquid crystal (LC) films for the detection of cholic acid (CA). This platform has the advantage of low cost, label-free, solution phase detection and simple analysis. In this platform, LC film of 4-Cyano-4'-pentylbiphenyl (5CB) was hosted by a copper grid supported with a polyimide-coated glass substrate. By immersing into sodium dodecyl sulfate (SDS) solution, the LC film was coated with SDS which induced a homeotropic anchoring of 5CB. Addition of CA introduced competitive adsorption between CA and SDS at the interface, triggering a transition from homeotropic to homogeneous anchoring. The detection limit can be tuned by changing the pH value of the solution from 12uM to 170uM.
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Sihui He, Sihui He, Wenlang Liang, Wenlang Liang, Colleen Tanner, Colleen Tanner, Jiyu Fang, Jiyu Fang, Shin-Tson Wu, Shin-Tson Wu, } "Liquid crystal based biosensors for bile acid detection", Proc. SPIE 8642, Emerging Liquid Crystal Technologies VIII, 86420P (5 March 2013); doi: 10.1117/12.2004170; https://doi.org/10.1117/12.2004170
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