Computer simulations have played an important role in the design and evaluation of imaging sensors with applications in
remote sensing and consumer photography. In this paper, we provide an example of computer simulations used
to guide the design of imaging sensors for a biomedical application: We consider how sensor design, illumination,
measurement geometry, and skin type influence the ability to detect blood oxygen saturation from non-invasive
measurements of skin reflectance. The methodology we describe in this paper can be used to design, simulate and
evaluate the design of other biomedical imaging systems.