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6 March 2013 Comparison of correction methods for bronchial lumen and wall thickness measurement using a physical tube array phantom
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Proceedings Volume 8668, Medical Imaging 2013: Physics of Medical Imaging; 86684W (2013)
Event: SPIE Medical Imaging, 2013, Lake Buena Vista (Orlando Area), Florida, United States
To facilitate systematic calibration and validation of quantitative airway measurements on CT for COPD diagnosis, an acrylic plastic phantom has been designed with an array of cylindrical tubes varying lumen diameter and wall thickness in a systematic way, which can be manufactured by inexpensive 3D-printing. Accuracy and reproducibility of the 3Dprinting have been confirmed by CT measurements. The multipliable, unobtrusive phantom can be scanned simultaneously with the patient for each exam, allows scan-specific calibration, and can thus improve multicenter study comparability between differing clinical imaging protocols. Three different methods to correct the bronchial measurements for partial volume effect and scanner blur were tested. The correction methods were variants of the physically motivated method suggested by Weinheimer et al. which integrates the Hounsfield densities in a certain wall area, and derives the corrected values assuming a characteristic constant Hounsfield density of the bronchial wall. The alternative methods compared here differ in the choice of the integration boundaries. Analysis of CT scans showed high agreement and good noise robustness of all correction methods on the one hand, but significant dependency on the choice of the CT reconstruction filter on the other hand, which emphasizes the benefits of scan-specific calibration.
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Rafael Wiemker, Udo van Stevendaal, Holger Schmitt, Amnon Steinberg, Ekta Dharaiya, Mark Rabotnikov, and Tobias Klinder "Comparison of correction methods for bronchial lumen and wall thickness measurement using a physical tube array phantom", Proc. SPIE 8668, Medical Imaging 2013: Physics of Medical Imaging, 86684W (6 March 2013); doi: 10.1117/12.2006236;

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