Shape deformations and volumetric changes in the hippocampus and amygdala have previously been noted in Major
Depressive Disorder (MDD). Unfortunately, these analyses are limited because relative shape and pose (rigid+scale
transformation) information of multiple objects in brain are generally disregarded. We hypothesize that this information
might complement studies of limbic structural deformation in MDD. We focus on changes in temporal (e.g., superior,
middle and inferior temporal gyrus) and limbic (e.g., hippocampus and amygdala) lobes. Here, we use a multi-object
statistical pose and shape model to analyze imaging data from young people with and without a depressive disorder.
Nineteen individuals with a depressive disorder (mean age: 17.85) and twenty six healthy controls (age: 18) were
enrolled in the study. A segmented atlas in MNI space has been used to segment hippocampus, amygdala,
parahippocampal gyri, putamen, and the superior, inferior and middle temporal gyri in both hemispheres of the brain.
Points on the surface of each structure were extracted and warped to each subjects’ structural MRI. These corresponding
surface points were used within the analysis, to extract the pose and shape features. Pose and shape differences were
detected between the two groups, such that second principal mode of pose variation (p = 0.022), and first principal mode
of shape variation (p = 0.049) were found to differ significantly between the two groups.