Lateral ventricle morphology analysis via mean latitude axis

Beatriz Paniagua; Amanda Lyall; Jean-Baptiste Berger; Clement Vachet; Robert M. Hamer; Sandra Woolson; Weili Lin; John Gilmore; Martin Styner

doi:10.1117/12.2006846

29 March 2013 Lateral ventricle morphology analysis via mean latitude axis

Beatriz Paniagua, Amanda Lyall, Jean-Baptiste Berger, Clement Vachet, Robert M. Hamer, Sandra Woolson, Weili Lin, John Gilmore, Martin Styner

Author Affiliations +

Proceedings Volume 8672, Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging; 86720M (2013) https://doi.org/10.1117/12.2006846
Event: SPIE Medical Imaging, 2013, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

Statistical shape analysis has emerged as an insightful method for evaluating brain structures in neuroimaging studies, however most shape frameworks are surface based and thus directly depend on the quality of surface alignment. In contrast, medial descriptions employ thickness information as alignment-independent shape metric. We propose a joint framework that computes local medial thickness information via a mean latitude axis from the well-known spherical harmonic (SPHARM-PDM) shape framework. In this work, we applied SPHARM derived medial representations to the morphological analysis of lateral ventricles in neonates. Mild ventriculomegaly (MVM) subjects are compared to healthy controls to highlight the potential of the methodology. Lateral ventricles were obtained from MRI scans of neonates (9-144 days of age) from 30 MVM subjects as well as age- and sex-matched normal controls (60 total). SPHARM-PDM shape analysis was extended to compute a mean latitude axis directly from the spherical parameterization. Local thickness and area was straightforwardly determined. MVM and healthy controls were compared using local MANOVA and compared with the traditional SPHARM-PDM analysis. Both surface and mean latitude axis findings differentiate successfully MVM and healthy lateral ventricle morphology. Lateral ventricles in MVM neonates show enlarged shapes in tail and head. Mean latitude axis is able to find significant differences all along the lateral ventricle shape, demonstrating that local thickness analysis provides significant insight over traditional SPHARM-PDM. This study is the first to precisely quantify 3D lateral ventricle morphology in MVM neonates using shape analysis.

Citation Download Citation

Beatriz Paniagua, Amanda Lyall, Jean-Baptiste Berger, Clement Vachet, Robert M. Hamer, Sandra Woolson, Weili Lin, John Gilmore, and Martin Styner "Lateral ventricle morphology analysis via mean latitude axis", Proc. SPIE 8672, Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging, 86720M (29 March 2013); https://doi.org/10.1117/12.2006846

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