Longitudinal assessment of treatment effects on pulmonary ventilation using 1H/3He MRI multivariate templates

Nicholas J. Tustison; Benjamin Contrella; Talissa A. Altes; Brian B. Avants; Eduard E. de Lange; John P. Mugler III

doi:10.1117/12.2006951

29 March 2013 Longitudinal assessment of treatment effects on pulmonary ventilation using 1H/3He MRI multivariate templates

Nicholas J. Tustison, Benjamin Contrella, Talissa A. Altes, Brian B. Avants, Eduard E. de Lange, John P. Mugler III

Author Affiliations +

Proceedings Volume 8672, Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging; 86720Y (2013) https://doi.org/10.1117/12.2006951
Event: SPIE Medical Imaging, 2013, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

The utitlity of pulmonary functional imaging techniques, such as hyperpolarized 3He MRI, has encouraged their inclusion in research studies for longitudinal assessment of disease progression and the study of treatment effects. We present methodology for performing voxelwise statistical analysis of ventilation maps derived from hyper polarized 3He MRI which incorporates multivariate template construction using simultaneous acquisition of IH and 3He images. Additional processing steps include intensity normalization, bias correction, 4-D longitudinal segmentation, and generation of expected ventilation maps prior to voxelwise regression analysis. Analysis is demonstrated on a cohort of eight individuals with diagnosed cystic fibrosis (CF) undergoing treatment imaged five times every two weeks with a prescribed treatment schedule.

Citation Download Citation

Nicholas J. Tustison, Benjamin Contrella, Talissa A. Altes, Brian B. Avants, Eduard E. de Lange, and John P. Mugler III "Longitudinal assessment of treatment effects on pulmonary ventilation using 1H/3He MRI multivariate templates", Proc. SPIE 8672, Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging, 86720Y (29 March 2013); https://doi.org/10.1117/12.2006951

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