Introducing nuclei scatterer patterns into histology based intravascular ultrasound simulation framework

Silvan Kraft; Athanasios Karamalis; Debdoot Sheet; Enken Drecoll; Ernst J. Rummeny; Nassir Navab; Peter B. Noël; Amin Katouzian

doi:10.1117/12.2006523

29 March 2013 Introducing nuclei scatterer patterns into histology based intravascular ultrasound simulation framework

Silvan Kraft, Athanasios Karamalis, Debdoot Sheet, Enken Drecoll, Ernst J. Rummeny, Nassir Navab, Peter B. Noël, Amin Katouzian

Author Affiliations +

Proceedings Volume 8675, Medical Imaging 2013: Ultrasonic Imaging, Tomography, and Therapy; 86750Y (2013) https://doi.org/10.1117/12.2006523
Event: SPIE Medical Imaging, 2013, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

Medical ultrasonic grayscale images are formed from acoustic waves following their interactions with distributed scatterers within tissues media. For accurate simulation of acoustic wave propagation, a reliable model describing unknown parameters associated with tissues scatterers such as distribution, size and acoustic properties is essential. In this work, we introduce a novel approach defining ultrasonic scatterers by incorporating a distribution of cellular nuclei patterns in biological tissues to simulate ultrasonic response of atherosclerotic tissues in intravascular ultrasound (IVUS). For this reason, a virtual phantom is generated through manual labeling of different tissue types (fibrotic, lipidic and calcified) on histology sections. Acoustic properties of each tissue type are defined by assuming that the ultrasound signal is primarily backscattered by the nuclei of the organic cells within the intima and media of the vessel wall. This resulting virtual phantom is subsequently used to simulate ultrasonic wave propagation through the tissue medium computed using finite difference estimation. Subsequently B-mode images for a specific histological section are processed from the simulated radiofrequency (RF) data and compared with the original IVUS of the same tissue section. Real IVUS RF signals for these histological sections were obtained using a single-element mechanically rotating 40MHz transducer. Evaluation is performed by trained reviewers subjectively assessing both simulated and real B-mode IVUS images. Our simulation platform provides a high image quality with a very promising correlation to the original IVUS images. This will facilitate to better understand progression of such a chronic disease from micro-level and its integration into cardiovascular disease-specific models.

Citation Download Citation

Silvan Kraft, Athanasios Karamalis, Debdoot Sheet, Enken Drecoll, Ernst J. Rummeny, Nassir Navab, Peter B. Noël, and Amin Katouzian "Introducing nuclei scatterer patterns into histology based intravascular ultrasound simulation framework", Proc. SPIE 8675, Medical Imaging 2013: Ultrasonic Imaging, Tomography, and Therapy, 86750Y (29 March 2013); https://doi.org/10.1117/12.2006523

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available