29 March 2013 Nonlinear response of lipid-shelled microbubbles to coded excitation: implications for noninvasive atherosclerosis imaging
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Abstract
Nonlinear (subharmonic/harmonic) imaging with ultrasound contrast agents (UCA) could characterize the vasa vasorum, which could help assess the risk associated with atherosclerosis. However, the sensitivity and specificity of high-frequency nonlinear imaging must be improved to enable its clinical translation. The current excitation scheme employs sine-bursts — a strategy that requires high-peak pressures to produce strong nonlinear response from UCA. In this paper, chirp-coded excitation was evaluated to assess its ability to enhance the subharmonic and harmonic response of UCA. Acoustic measurements were conducted with a pair of single-element transducers at 10-MHz transmit frequencies to evaluate the subharmonic and harmonic response of Targestar-P® (Targeson Inc., San Diego, CA, USA), a commercially available phospholipid-encapsulated contrast agent. The results of this study demonstrated a 2 - 3 fold reduction in the subharmonic threshold, and a 4 - 14 dB increase in nonlinear signal-to-noise ratio, with chirp-coded excitation. Therefore, chirp-coded excitation could be well suited for improving the imaging performance of high-frequency harmonic and subharmonic imaging.
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Himanshu Shekhar, Himanshu Shekhar, Marvin M. Doyley, Marvin M. Doyley, } "Nonlinear response of lipid-shelled microbubbles to coded excitation: implications for noninvasive atherosclerosis imaging", Proc. SPIE 8675, Medical Imaging 2013: Ultrasonic Imaging, Tomography, and Therapy, 867510 (29 March 2013); doi: 10.1117/12.2007065; https://doi.org/10.1117/12.2007065
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