29 March 2013 Development of a 3D ultrasound system to investigate post-hemorrhagic hydrocephalus in pre-term neonates
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Abstract
Clinical intracranial ultrasound (US) is performed as a standard of care on neonates at risk of intraventricular hemorrhaging (IVH) and is also used after a diagnosis to monitor for potential ventricular dilation. However, it is difficult to estimate the volume of ventricles with 2D US due to their irregular shape. We developed a 3D US system to be used as an adjunct to a clinical system to investigate volumetric changes in the ventricles of neonates with IVH. Our system has been found have an error of within 1% of actual distance measurements in all three directions and volume measurements of manually segmented volumes from phantoms were not statistically significantly different from the actual values (p>0.3). Interobserver volume measurements of the lateral ventricles in a patient with grade III IVH found no significant differences between measurements. There is the potential to use this system in IVH patients to monitor the progression of ventriculomegaly over time.
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J. Kishimoto, D. Lee, K. St. Lawrence, W. Romano, A. Fenster, S. de Ribaupierre, "Development of a 3D ultrasound system to investigate post-hemorrhagic hydrocephalus in pre-term neonates", Proc. SPIE 8675, Medical Imaging 2013: Ultrasonic Imaging, Tomography, and Therapy, 86751M (29 March 2013); doi: 10.1117/12.2006646; https://doi.org/10.1117/12.2006646
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