29 March 2013 Novel chromatin texture features for the classification of pap smears
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Proceedings Volume 8676, Medical Imaging 2013: Digital Pathology; 867608 (2013) https://doi.org/10.1117/12.2007185
Event: SPIE Medical Imaging, 2013, Lake Buena Vista (Orlando Area), Florida, United States
Abstract
This paper presents a set of novel structural texture features for quantifying nuclear chromatin patterns in cells on a conventional Pap smear. The features are derived from an initial segmentation of the chromatin into bloblike texture primitives. The results of a comprehensive feature selection experiment, including the set of proposed structural texture features and a range of different cytology features drawn from the literature, show that two of the four top ranking features are structural texture features. They also show that a combination of structural and conventional features yields a classification performance of 0.954±0.019 (AUC±SE) for the discrimination of normal (NILM) and abnormal (LSIL and HSIL) slides. The results of a second classification experiment, using only normal-appearing cells from both normal and abnormal slides, demonstrates that a single structural texture feature measuring chromatin margination yields a classification performance of 0.815±0.019. Overall the results demonstrate the efficacy of the proposed structural approach and that it is possible to detect malignancy associated changes (MACs) in Papanicoloau stain.
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Babak Ehteshami Bejnordi, Babak Ehteshami Bejnordi, Ramin Moshavegh, Ramin Moshavegh, K. Sujathan, K. Sujathan, Patrik Malm, Patrik Malm, Ewert Bengtsson, Ewert Bengtsson, Andrew Mehnert, Andrew Mehnert, } "Novel chromatin texture features for the classification of pap smears", Proc. SPIE 8676, Medical Imaging 2013: Digital Pathology, 867608 (29 March 2013); doi: 10.1117/12.2007185; https://doi.org/10.1117/12.2007185
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