8 April 2013 Biomolecular hydrogel-based lipid bilayer array system
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Abstract
This work investigates the fabrication of hydrogel based lipid bilayers arrays using micro fabrication technologies that enable high precision in controlling the cell-scale droplets. Arrays of hydrogels that support curved aqueous lenses are deposited on two parallel substrates using lithography techniques on top of a network of Ag/AgCl electrodes. The first step in the fabrication process is to deposit silver electrodes using silver paint through a mask, a layer of silver chloride is then formed around the silver channels using another mask with the desired geometry. The hydrogel arrays are then achieved by exposing a thin film of photocrosslinkable hydrogel to UV light through a mask. Hydrogel arrays are fabricated using this technique, which is represents a relatively accurate and inexpensive method. The hydrogel structures can host a thin aqueous curved lenses containing phospholipids . Bilayer arrays can be formed by using a technique similar to the regulated attachment method, where mechanical force is used to bring adjacent aqueous lenses in contact.
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Joseph Najem, Joseph Najem, Alex Edgerton, Alex Edgerton, Donald J. Leo, Donald J. Leo, } "Biomolecular hydrogel-based lipid bilayer array system", Proc. SPIE 8686, Bioinspiration, Biomimetics, and Bioreplication 2013, 86860C (8 April 2013); doi: 10.1117/12.2010695; https://doi.org/10.1117/12.2010695
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