LGR5 expressing cells of hair follicle as potential targets for antibody mediated anti-cancer laser therapy

Boris V. Popov

doi:10.1117/12.2018463

26 February 2013 LGR5 expressing cells of hair follicle as potential targets for antibody mediated anti-cancer laser therapy

Boris V. Popov

Author Affiliations +

Proceedings Volume 8699, Saratov Fall Meeting 2012: Optical Technologies in Biophysics and Medicine XIV; and Laser Physics and Photonics XIV; 86990O (2013) https://doi.org/10.1117/12.2018463
Event: Saratov Fall Meeting and Workshop on Laser Physics and Photonics 2012, 2012, Saratov, Russian Federation

Abstract

Near infrared laser immunotherapy becomes now a new promising research field to cure the patients with cancers. One of the critical limitation in medical application of this treatment is availability of the specific markers for delivery of laser-sensitive nanoparticles. When coupled to antibodies to the cancer stem cells markers these nanoparticles may be delivered to the cancer tissue and mediate the laser induced thermolysis of the cancer stem cells that initiate and drive growth of cancer. This paper addresses the Lgr5 cell surface marker mediating the Wnt/β-catenin signal transduction as a potential target for anti-cancer laser immunotherapy of skin cancers.

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Boris V. Popov "LGR5 expressing cells of hair follicle as potential targets for antibody mediated anti-cancer laser therapy", Proc. SPIE 8699, Saratov Fall Meeting 2012: Optical Technologies in Biophysics and Medicine XIV; and Laser Physics and Photonics XIV, 86990O (26 February 2013); https://doi.org/10.1117/12.2018463

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