Systems biomarkers as acute diagnostics and chronic monitoring tools for traumatic brain injury

Kevin K. W. Wang; Ahmed Moghieb; Zhihui Yang; Zhiqun Zhang

doi:10.1117/12.2020030

29 May 2013 Systems biomarkers as acute diagnostics and chronic monitoring tools for traumatic brain injury

Kevin K. W. Wang, Ahmed Moghieb, Zhihui Yang, Zhiqun Zhang

Proceedings Volume 8723, Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring III; 87230O (2013) https://doi.org/10.1117/12.2020030
Event: SPIE Defense, Security, and Sensing, 2013, Baltimore, Maryland, United States

Abstract

Traumatic brain injury (TBI) is a significant biomedical problem among military personnel and civilians. There exists an urgent need to develop and refine biological measures of acute brain injury and chronic recovery after brain injury. Such measures “biomarkers” can assist clinicians in helping to define and refine the recovery process and developing treatment paradigms for the acutely injured to reduce secondary injury processes. Recent biomarker studies in the acute phase of TBI have highlighted the importance and feasibilities of identifying clinically useful biomarkers. However, much less is known about the subacute and chronic phases of TBI. We propose here that for a complex biological problem such as TBI, multiple biomarker types might be needed to harness the wide range of pathological and systemic perturbations following injuries, including acute neuronal death, neuroinflammation, neurodegeneration and neuroregeneration to systemic responses. In terms of biomarker types, they range from brain-specific proteins, microRNA, genetic polymorphism, inflammatory cytokines and autoimmune markers and neuro-endocrine hormones. Furthermore, systems biology-driven biomarkers integration can help present a holistic approach to understanding scenarios and complexity pathways involved in brain injury.

Citation Download Citation

Kevin K. W. Wang, Ahmed Moghieb, Zhihui Yang, and Zhiqun Zhang "Systems biomarkers as acute diagnostics and chronic monitoring tools for traumatic brain injury", Proc. SPIE 8723, Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring III, 87230O (29 May 2013); https://doi.org/10.1117/12.2020030

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