29 May 2013 The toxic effects of flame retardants: a gene expression study in elucidating their carcinogenicity
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Abstract
Polybrominated Diphenyl Ethers (PBDEs) are flame retardants widely used in many commercial products, including building materials, electronics, furnishings, motor vehicles, airplanes, plastics, polyurethane foams, and textiles. Although the specific toxic action of these chemicals is not clear, it is reported that they can cause serious damage to the nervous, reproductive, and endocrine systems. These chemicals are branded as “probable carcinogens” by Environmental Protection Agency (EPA). Therefore, this study is taken up to investigate the expression of genes namely, TP-53, RAD1, CRADD, and ATM, which are involved in apoptosis, DNA repair and cell cycle regulation. For this study human umbilical vein endothelial cells (HUVEC) are exposed to 5 μM of BDE-85 (a penta-BDE) and BDE-209 (deca-BDE). The results of this report reveal significant alteration in all the genes under investigation in BDE-85 and BDE-209 exposed cells. The BDE-85 induced responses are significantly more than BDE-209. These results emphasize the congener specific action of PBDEs on the expression of genes relevant to DNA repair and cell division of HUVEC cells.
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Mary Vagula, Mary Vagula, Ali Al-Dhumani, Ali Al-Dhumani, Sajaad Al-Dhumani, Sajaad Al-Dhumani, Alexandra Mastro, Alexandra Mastro, "The toxic effects of flame retardants: a gene expression study in elucidating their carcinogenicity", Proc. SPIE 8723, Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring III, 87231D (29 May 2013); doi: 10.1117/12.2016327; https://doi.org/10.1117/12.2016327
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