Design of readout-integrated circuit(ROIC) with high frequency and low signal for 512×256 short wavelength(SW) inferred-focal-plane-arrays(IRFPAs) is presented. The ROIC with high performance in frame rate can integrate and read out the low signal. An analog signal chain, which contains CTIA, CDS module, amplifier of charge and complementary output stage, can satisfy the high frequency and low signal application. A reliable digital control structure of IRFPA ROIC is presented, with which the integral voltage of arbitrary contiguous or noncontiguous lines, rather than regular lines, can be selected to readout. The simulation and verification are completed both before and after completing the layout. The circuit’s structure and operation principle are analyzed under the environment of mix-signal, and the result shows that the output dynamic range is over 2.5V, the charge capacity is more than 1Me-, the frame rate is 250Hz, the linearity within useful dynamic range is above 99.9 percent.