28 May 2013 Cell array fabrication by plasma nanotexturing
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Abstract
Cell behavior (i.e. attachment, proliferation, etc.) on nanostructured surfaces is currently a hot topic throughout the scientific community. However, studies often show diverging results due to differences in cells, local surface chemistry, and nanotopography fabrication methods. In this study, we use Oxygen plasma etching to both randomly nanotexture a PMMA surface and change its surface chemistry. We find that 3T3 cells behave quite differently on flat PMMA surfaces as compared to nanotextured ones, showing an on-off attachment behavior. Work is under progress to exploit this effect allowing selective cell capturing, and creation of cell arrays in adjacent plasma-nanotextured/smooth areas using a stencil mask during etching.
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Dimitrios Kontziampasis, Dimitrios Kontziampasis, Athanasia Bourkoula, Athanasia Bourkoula, Panagiota Petrou, Panagiota Petrou, Angeliki Tserepi, Angeliki Tserepi, Sotirios Kakabakos, Sotirios Kakabakos, Evangelos Gogolides, Evangelos Gogolides, "Cell array fabrication by plasma nanotexturing", Proc. SPIE 8765, Bio-MEMS and Medical Microdevices, 87650B (28 May 2013); doi: 10.1117/12.2017894; https://doi.org/10.1117/12.2017894
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