Fano lineshapes of 'Peak-tracking chip' spatial profiles analyzed with correlation analysis for bioarray imaging and refractive index sensing

K. Bougot-Robin; S. Li; W. Yue; L. Q. Chen; X. X. Zhang; W. J. Wen; H. Benisty

doi:10.1117/12.2018316

22 May 2013 Fano lineshapes of 'Peak-tracking chip' spatial profiles analyzed with correlation analysis for bioarray imaging and refractive index sensing

K. Bougot-Robin, S. Li, W. Yue, L. Q. Chen, X. X. Zhang, W. J. Wen, H. Benisty

Author Affiliations +

Proceedings Volume 8767, Integrated Photonics: Materials, Devices, and Applications II; 876703 (2013) https://doi.org/10.1117/12.2018316
Event: SPIE Microtechnologies, 2013, Grenoble, France

Abstract

The asymmetric Fano resonance lineshapes, resulting from interference between background and a resonant scattering, is archetypal in resonant waveguide grating (RWG) reflectivity. Resonant profile shift resulting from a change of refractive index (from fluid medium or biomolecules at the chip surface) is classically used to perform label-free sensing. Lineshapes are sometimes sampled at discretized “detuning” values to relax instrumental demands, the highest reflectivity element giving a coarse resonance estimate. A finer extraction, needed to increase sensor sensitivity, can be obtained using a correlation approach, correlating the sensed signal to a zero-shifted reference signal. Fabrication process is presented leading to discrete Fano profiles. Our findings are illustrated with resonance profiles from silicon nitride RWGs operated at visible wavelengths. We recently demonstrated that direct imaging multi-assay RWGs sensing may be rendered more reliable using “chirped” RWG chips, by varying a RWG structure parameter. Then, the spatial reflectivity profiles of tracks composed of RWGs units with slowly varying filling factor (thus slowly varying resonance condition) are measured under monochromatic conditions. Extracting the resonance location using spatial Fano profiles allows multiplex refractive index based sensing. Discretization and sensitivity are discussed both through simulation and experiment for different filling factor variation, here Δf=0.0222 and Δf=0.0089. This scheme based on a “Peak-tracking chip” demonstrates a new technique for bioarray imaging using a simpler set-up that maintains high performance with cheap lenses, with down to Δn=2×10^-5 RIU sensitivity for the highest sampling of Fano lineshapes.

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K. Bougot-Robin, S. Li, W. Yue, L. Q. Chen, X. X. Zhang, W. J. Wen, and H. Benisty "Fano lineshapes of 'Peak-tracking chip' spatial profiles analyzed with correlation analysis for bioarray imaging and refractive index sensing", Proc. SPIE 8767, Integrated Photonics: Materials, Devices, and Applications II, 876703 (22 May 2013); https://doi.org/10.1117/12.2018316

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KEYWORDS

Refractive index

Reflectivity

Waveguides

Biological research

Biosensing

Silicon

Water

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