Multianalyte detection using fiber optic particle plasmon resonance sensor based on plasmonic light scattering interrogation

Hsing-Ying Lin; Chen-Han Huang; Lai-Kwan Chau

doi:10.1117/12.2017321

3 May 2013 Multianalyte detection using fiber optic particle plasmon resonance sensor based on plasmonic light scattering interrogation

Hsing-Ying Lin, Chen-Han Huang, Lai-Kwan Chau

Author Affiliations +

Proceedings Volume 8774, Optical Sensors 2013; 877408 (2013) https://doi.org/10.1117/12.2017321
Event: SPIE Optics + Optoelectronics, 2013, Prague, Czech Republic

Abstract

A highly sensitive fiber optic particle plasmon resonance sensor (FO-PPR) is demonstrated for label-free biochemical detection. The sensing strategy relies on interrogating the plasmonic scattering of light from gold nanoparticles on the optical fiber in response to the surrounding refractive index changes or molecular binding events. The refractive index resolution is estimated to be 3.8 × 10⁻⁵ RIU. The limit of detection for anti-DNP antibody spiked in buffer is 1.2 × 10⁻⁹ g/ml (5.3 pM) by using the DNP-functionalized FO-PPR sensor. The image processing of simultaneously recorded plasmonic scattering photographs at different compartments of the sensor is also demonstrated. Results suggest that the compact sensor can perform multiple independent measurements simultaneously by means of monitoring the plasmonic scattering intensity via photodiodes or a CCD. The potential of using a combination of different kinds of noble metal nanoparticles with different types of functionalized probes in multiple cascaded detection windows on a single fiber to become an inexpensive and ultrasensitive linear-array sensing platform for higher-throughput biochemical detection is provided.

Citation Download Citation

Hsing-Ying Lin, Chen-Han Huang, and Lai-Kwan Chau "Multianalyte detection using fiber optic particle plasmon resonance sensor based on plasmonic light scattering interrogation", Proc. SPIE 8774, Optical Sensors 2013, 877408 (3 May 2013); https://doi.org/10.1117/12.2017321

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KEYWORDS

Sensors

Scattering

Plasmonics

Light scattering

Nanoparticles

Fiber optics sensors

Refractive index

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