23 May 2013 Characterization of a bioinspired elastin-polypropylene fumarate material for vascular prostheses applications
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Vascular prostheses are widely used devices fundamental to avoid the effect of life-threatening diseases and defects. Besides a long experience in the fabrication of biomaterials for vascular applications, many issues still remain unattended. In particular, obtaining a bio-resorbable and bio-active scaffold is a challenge of paramount importance. We present a novel application in which a promising biodegradable polymer, poly-propylene fumarate (PPF), is printed using three dimensional laser-induced cross-linking micromachining device. To enhance the biological role of the scaffold, a bio-inspired approach was taken, by coating the surface of the PPF with elastin, the main constituent of the innermost layer of natural veins and arteries.
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Silvia Scaglione, Silvia Scaglione, Rossella Barenghi, Rossella Barenghi, Szabolcs Beke, Szabolcs Beke, Luca Ceseracciu, Luca Ceseracciu, Ilaria Romano, Ilaria Romano, Francesca Sbrana, Francesca Sbrana, Paola Stagnaro, Paola Stagnaro, Fernando Brandi, Fernando Brandi, Massimo Vassalli, Massimo Vassalli, "Characterization of a bioinspired elastin-polypropylene fumarate material for vascular prostheses applications", Proc. SPIE 8792, Optical Methods for Inspection, Characterization, and Imaging of Biomaterials, 87920H (23 May 2013); doi: 10.1117/12.2021754; https://doi.org/10.1117/12.2021754

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