23 May 2013 Non-invasive continuous imaging of drug release from soy-based skin equivalent using wide-field interferometry
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Abstract
We propose an off-axis interferometric imaging system as a simple and unique modality for continuous, non-contact and non-invasive wide-field imaging and characterization of drug release from its polymeric device used in biomedicine. In contrast to the current gold-standard methods in this field, usually based on chromatographic and spectroscopic techniques, our method requires no user intervention during the experiment, and only one test-tube is prepared. We experimentally demonstrate imaging and characterization of drug release from soy-based protein matrix, used as skin equivalent for wound dressing with controlled anesthetic, Bupivacaine drug release. Our preliminary results demonstrate the high potential of our method as a simple and low-cost modality for wide-field imaging and characterization of drug release from drug delivery devices.
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Haniel Gabai, Haniel Gabai, Maya Baranes-Zeevi, Maya Baranes-Zeevi, Meital Zilberman, Meital Zilberman, Natan T. Shaked, Natan T. Shaked, } "Non-invasive continuous imaging of drug release from soy-based skin equivalent using wide-field interferometry", Proc. SPIE 8792, Optical Methods for Inspection, Characterization, and Imaging of Biomaterials, 879215 (23 May 2013); doi: 10.1117/12.2020485; https://doi.org/10.1117/12.2020485
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