Satellite time-series data, coupled with ground based observations where available, can enable scientists to survey pre-earthquake signals in the areas of strong tectonic activity. Cumulative stress energy in seismic active regions under operating tectonic force manifests various earthquakes’ precursors. Space-time anomalies of Earth’s emitted radiation (radon in underground water and soil, thermal infrared in spectral range measured from satellite months to weeks before the occurrence of earthquakes etc.), and electromagnetic anomalies are considered as pre-seismic signals. This energy transformation may result in enhanced transient thermal infrared (TIR) emission, which can be detected through satellites equipped with thermal sensors like AVHRR (NOAA), MODIS (Terra/Aqua). This paper presents observations made using time series NOAA-AVHRR and MODIS satellite data–derived land surface temperature (LST) and outgoing longwave radiation (OLR) values in case of 27th 2004 earthquake recorded in seismic Vrancea region, Romania, using anomalous TIR signals as reflected in LST rise and high OLR values which followed similar growth pattern spatially and temporally. In all analyzed cases, starting with almost one week prior to a moderate or strong earthquake a transient thermal infrared rise in LST of several Celsius degrees (°C) and the increased OLR values higher than the normal have been recorded around epicentral areas, function of the magnitude and focal depth, which disappeared after the main shock. As Vrancea area has a significant regional tectonic activity in Romania and Europe, the joint analysis of geospatial and in-situ geophysical information is revealing new insights in the field of hazard assessment.