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14 June 2013 Bioluminescence tomography improves quantitative accuracy for pre-clinical imaging
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A study is presented that demonstrates that bioluminescence tomography can reconstruct accurate 3D images of internal light sources placed at a range of depths within a physical phantom and that it provides more reliable quantitative data than standard bioluminescence imaging. Specifically, it is shown that when imaging sources at depths ranging from 5 to 15mm, estimates of total source strength are stable to within ±11% using tomography whilst values deduced by traditional methods vary 10-fold. Additionally, the tomographic approach correctly localises sources to within 1.5mm error in all cases considered.
© (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
James A. Guggenheim, Hector R. A. Basevi, Iain B. Styles, Jon Frampton, and Hamid Dehghani "Bioluminescence tomography improves quantitative accuracy for pre-clinical imaging", Proc. SPIE 8799, Diffuse Optical Imaging IV, 87990G (14 June 2013);

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