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14 June 2013 Bioluminescence tomography improves quantitative accuracy for pre-clinical imaging
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Abstract
A study is presented that demonstrates that bioluminescence tomography can reconstruct accurate 3D images of internal light sources placed at a range of depths within a physical phantom and that it provides more reliable quantitative data than standard bioluminescence imaging. Specifically, it is shown that when imaging sources at depths ranging from 5 to 15mm, estimates of total source strength are stable to within ±11% using tomography whilst values deduced by traditional methods vary 10-fold. Additionally, the tomographic approach correctly localises sources to within 1.5mm error in all cases considered.
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James A. Guggenheim, Hector R. A. Basevi, Iain B. Styles, Jon Frampton, and Hamid Dehghani "Bioluminescence tomography improves quantitative accuracy for pre-clinical imaging", Proc. SPIE 8799, Diffuse Optical Imaging IV, 87990G (14 June 2013); https://doi.org/10.1117/12.2033317
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